Centralised Transcutaneous Monitoring using IOT

Abstract

The centralized transcutaneous monitoring using internet of things (IoT) is a cutting-edge healthcare approach that makes use of IoT technology\'s promise to revolutionize remote patient monitoring. The goal of this work is to enable healthcare professionals to remotely access and monitor crucial patient data to provide fast and accurate diagnoses. The proposed work creates a framework for collecting patient data from transcutaneous monitoring devices by seamlessly integrating IoT devices equipped with WiFi modules. then, this data is sent to the Azure IoT Hub, a cloud-based platform that enables safe, privacy management and storage. According to the Agile methodology, the project progresses through numerous significant phases. These include upgrading the operating system from Windows Embedded Compact (WEC7) to the more modern WEC13, integrating WiFi through Node MCU, establishing a secure data transmission channel between IoT devices and Azure IoT Hub, creating a user-centric web portal using Angular JS, and working actively with the marketing department to match the project with the changing requirements of the healthcare industry. These efforts culminate in an online portal that provides real-time patient data to healthcare providers. This interface provides a wide range of features, such as data visualizations, detailed graphs, and device-specific insights. The initiative redefines the boundaries of patient monitoring and diagnostics, serving as a symbol of the synergy between cutting-edge technology and medical care. The data can be viewed anytime and anywhere by the doctors.

Introduction

I. INTRODUCTION

Every aspect of healthcare demands meticulous attention. Each device in use must operate flawlessly and without faults because even the slightest deviation from a device's essential parameter readings could lead a medical practitioner to make a risky and incorrect diagnosis.

Based on the data displayed on the equipment, healthcare providers offer diagnoses to patients. It's essential to provide regular updates to the individuals concerned. However, medical practitioners cannot spend their entire time fixated on the instruments. This project focuses on addressing this challenge.

The project is a part of a verification process designed to demonstrate that specific concepts or theories have real-world practical applications. This demonstration involves creating a prototype to assess feasibility, though the prototype itself does not constitute the final deliverables.

Consequently, the term holds different meanings in various domains. In software development, it encompasses distinct processes with diverse goals and participant roles. In this context, it might refer to partial solutions engaging a small user group in business roles to verify system requirements. The primary objective of this process is to discover solutions to technical hurdles, such as integrating systems or achieving optimal throughput through a specific configuration.

The objective of this project is to switch the operating system (OS) of the TCM device from WEC7 to WEC13, while also activating the Wi-Fi module in the transcutaneous monitoring device using the Node MCU, an IoT device. Subsequently, data is sent to the Azure IoT hub and stored in Azure storage, integrated into a web application developed using AngularJS. The overarching idea is to display live vital parameters and alerts from a transcutaneous monitoring device on a web portal. To achieve this, a web server is developed, and necessary code modifications are made to enable continuous transmission of vital parameters and alerts to the cloud. A separate storage system is created to house this data.

Incorporating an operating system (OS) change into this project can yield numerous advantages, such as enhanced performance, bolstered security measures, improved compatibility, access to novel features, expansion of the software ecosystem, and the assurance of long-term support. Simultaneously, sensors consistently track the patient's vital signs, transmitting the collected data to the Azure cloud for subsequent storage and analysis. In tandem, the web application provides a user-friendly interface, empowering healthcare providers to conveniently monitor the patient's health status from anywhere with an internet connection.

II. RELATED WORK

The paper [1] focus on provide a comprehensive survey of IoT-based wearable health monitoring systems. It covers various aspects of these systems, including wearable sensor technologies, data acquisition and transmission, data processing and analysis, and applications in healthcare. The authors discuss the challenges and future directions in the field, highlighting the potential benefits of IoT-based wearable health monitoring systems in improving healthcare delivery and patient outcomes.

It presents an IoT-enabled remote health monitoring system that utilizes wearable sensors in paper [2]. It describes the system architecture, including wearable devices, data transmission protocols, and cloud-based data storage. The authors showcase the application of the system in monitoring various health parameters and provide insights into the implementation challenges and potential solutions. The paper emphasizes the importance of remote health monitoring for timely intervention and improved healthcare management.

It addresses the issue of secure and efficient data transmission in IoT-based health monitoring systems. It discusses various encryption and authentication techniques to ensure the privacy and integrity of data during transmission in paper [3]. The authors propose a secure data transmission framework and evaluate its performance in terms of data security, communication overhead, and energy efficiency. The paper highlights the importance of secure data transmission in protecting sensitive health information and maintaining the trustworthiness of IoT-based health monitoring systems.

In paper [4] it explains the concept of continuous health monitoring using IoT and edge computing. It discusses the integration of wearable devices, edge computing nodes, and cloud platforms to enable real-time data collection, processing, and storage. The authors highlight the benefits of edge computing in reducing latency, ensuring data privacy, and enhancing system scalability. The paper presents a prototype implementation and discusses the potential applications and future research directions in continuous health monitoring. It presents a real-time patient health monitoring system based on IoT and cloud computing. It focuses on the design and implementation of the system architecture, including wearable sensors, data transmission protocols, cloud-based storage, and real-time data analytics in paper [5]. The authors highlight the benefits of the system in facilitating remote patient monitoring, enabling timely interventions, and improving healthcare outcomes. The paper also discusses the challenges and considerations in deploying such systems in healthcare settings. It presents the development of an IoT-based wearable sensor system for remote patient monitoring in paper [6]. It describes the design and implementation of the wearable sensor device, data acquisition and transmission protocols, and cloud-based data storage and analysis. The authors showcase the application of the system in monitoring vital signs and health parameters of patients in real-time. The paper discusses the feasibility and potential benefits of the IoT-based wearable sensor system in improving healthcare outcomes and enabling remote patient monitoring.

It mainly focuses on smart health monitoring system that combines IoT and cloud computing technologies. It presents the architecture of the system, including wearable sensors, data transmission protocols, cloud-based data storage, and real-time analytics in paper [7]. The authors demonstrate the system's capabilities in monitoring various health parameters and generating alerts for timely intervention. The paper emphasizes the potential of the smart health monitoring system in improving healthcare delivery and facilitating remote patient monitoring.

A. Transcutaneous Monitoring

Transcutaneous monitoring is an innovative and highly accurate technology that provides continuous, non-invasive monitoring of oxygen and carbon dioxide. Its power and appeal derive from a simple principle: through a non- invasive sensor applied to the body, blood gases diffusing through the skin can be detected and estimated. The transcutaneous monitoring devices that used for this encompass many parameters, such as tcpCO2, tcpO2, SpO2 and pulse rate. Transcutaneous monitoring devices are excellent for use as a trending tool. They accurately monitor the patient’s status. This allows healthcare professionals to take immediate action when needed. As a result, patient safety and comfort are improved. It’s ideal for neonatal intensive care units (NICU) to monitor pre-term babies, monitoring and adjusting non - invasive ventilation (NIV) treatments and in sleep laboratories to track and diagnose sleep disorders. It’s also extremely well suited for the assessment of chronic wounds and vascular diseases.

B. Transcutaneous Monitoring

Transcutaneous monitoring is an innovative and highly accurate technology that provides continuous, non-invasive monitoring of oxygen and carbon dioxide. Its power and appeal derive from a simple principle: through a non- invasive sensor applied to the body, blood gases diffusing through the skin can be detected and estimated. The transcutaneous monitoring devices that used for this encompass many parameters, such as tcpCO2, tcpO2, SpO2 and pulse rate. Transcutaneous monitoring devices are excellent for use as a trending tool. They accurately monitor the patient’s status.

This allows healthcare professionals to take immediate action when needed. As a result, patient safety and comfort are improved. It’s ideal for neonatal intensive care units (NICU) to monitor pre-term babies, monitoring and adjusting non - invasive ventilation (NIV) treatments and in sleep laboratories to track and diagnose sleep disorders. It’s also extremely well suited for the assessment of chronic wounds and vascular diseases.

C. Transcutaneous Monitoring Device

This device is used to continuously monitor the Oxygen and Carbon dioxide levels of patients especially in case of preterm infants. It consists of a sensor which is placed on the skin. This sensor increases the temperature of the skin in that area slightly above the body temp. Due to this, gases in blood – CO2 and O2 get diffused from skin tissues. The sensor detects these gases and registers the quantity of O2, and CO2 present in the blood. If the amount of O2 and CO2 are too low, it indicates that some vital functions of the body are altered, and patient’s condition could get worse. This transcutaneous monitoring helps in immediate detection of changes in CO2 and O2 levels. In case of patients who are using ventilation for them this is very important as they require continuous monitoring of air supply. During surgery, this device plays an important role in ensuring correct amount of O2 and CO2 supply.

D. tcpCO2, tcpO2, SpO2 monitoring:

The transcutaneous carbon dioxide (tcpCO2) and transcutaneous oxygen (tcpO2) measuring techniques were first developed in the nineteen seventies. Since then, major further advances have been made and significantly improved the technology and practical application. Today, monitoring of transcutaneous gas tension is not only valuable for the respiratory and ventilatory status of neonates, but also highly relevant for the ventilatory care of children and adults with chronic respiratory failure. This development has followed the change in hospital care. As measurement of oxygen saturation by pulse oximetry (SpO2) is often used in combination with tcpCO2, and sometimes also tcpO2 monitoring.

Transcutaneous carbon dioxide and oxygen monitoring is a non-invasive way of continuously measuring the tension of these gases in the skin. A combined Clark-type and Severing Haus-type sensor also called Stow-Severing Haus sensor is placed on the skin and heated. The sensor heat dilates the underlying capillaries and increases the gas diffusion through the lipid structure of the skin, thereby allowing carbon dioxide and oxygen to diffuse up to 20 times more quickly from the capillaries through the skin to the sensor. The oxygen generates a current and the carbon dioxide a potential in the sensor. These signals are converted by the monitor and showed as tcpCO2 and tcpO2 values on the screen.

III. METHODOLOGY

Figure 1 depicts the proposed work. The envisioned system comprises four primary components: Node MCU-based sensors, an operating system (OS) update, the Azure cloud platform, and a web application designed for data monitoring and visualization. Implementing an OS update within the project holds the potential to yield several benefits, including performance enhancements, bolstered security measures, improved compatibility, access to novel features, an expanded software ecosystem, and sustained long-term support.

The core functionality of the system revolves around the Node MCU-based sensors, which continuously track a patient's vital signs. Subsequently, these sensors transmit the collected data to the Azure cloud infrastructure for storage and in-depth analysis. To facilitate efficient access and interpretation of this data, a user-friendly web application has been developed. This application empowers healthcare providers to seamlessly monitor the patient's health status from any location equipped with an internet connection.

A. TCM Device

Transcutaneous monitoring is the measurement of gases and other substances in the skin and underlying tissues. It also provides transcutaneous monitoring solutions for measuring oxygen and carbon dioxide levels. Transcutaneous monitoring is a non-invasive technique for measuring gases. It has been used for several decades to monitor oxygen and carbon dioxide levels in critically ill patients. Transcutaneous monitoring works on the principle of diffusion of gases across the skin. A sensor is placed on the skin and heated to a specific temperature. The sensor contains a small electrode that measures the concentration of gases, such as oxygen and carbon dioxide, in the skin. The concentration of gases in the skin is proportional to their concentration in the blood.

Transcutaneous monitoring is commonly used in neonatal intensive care units to monitor oxygen levels in premature infants. It is also used in the management of respiratory failure in adults, particularly in patients with chronic obstructive pulmonary disease (COPD) or acute respiratory distress syndrome (ARDS). It can also be used in the monitoring of patients undergoing mechanical ventilation, as well as during exercise testing in patients with cardiovascular or pulmonary disease. Although it has limitations, transcutaneous monitoring is a valuable tool in the management of respiratory and cardiovascular diseases, as well as in neonatal care. 

B. OS change

The table 1 describes the intended use of WEC7 to WEC13

Table 1: Intended Use

The main advantage of changing the operating system is that the newer versions of an operating system generally come with improved hardware compatibility. Upgrading to a newer version could mean better support for the latest hardware components and peripherals, ensuring that your embedded devices can take advantage of modern technology.

The Software updates often include security improvements to address vulnerabilities that have been discovered in older versions. Upgrading to a newer version of the operating system can provide enhanced security features and protection against emerging threats. Newer versions of an operating system might include performance optimizations that allow applications to run more efficiently. This could lead to better overall system performance and responsiveness.

C. Node MCU

Node MCU is an open-source electronics platform based on the ESP8266 WiFi module. It is designed to provide an easy and cost-effective way for hobbyists, makers, and developers to create Internet of Things (IoT) projects and connect devices to the internet. Node MCU combines a microcontroller unit (MCU) with built-in WiFi capabilities, making it suitable for a wide range of applications.

The Node MCU, a versatile platform built around the ESP8266 microcontroller is shown in figure 2, emerges as a linchpin in the evolution of transcutaneous monitoring technology. By seamlessly integrating a WiFi module into the TCM device, Node MCU instigates a revolutionary shift towards real-time data communication. Through meticulous utilization of its GPIO pins, Node MCU establishes a robust connection with the TCM device's serial port, creating an intricate data bridge.

In practice, as the TCM device non-invasively captures physiological data from the skin, Node MCU stands ready to convert this analog information into digital signals. These signals are swiftly channeled through the serial port, utilizing Node MCU's bidirectional capabilities to ensure the seamless flow of data. However, Node MCU's role doesn't halt at data transmission; it extends its reach further by embracing the prowess of cloud technology. By seamlessly interfacing with the Azure cloud, Node MCU transcends the confines of physical data storage. The captured physiological data is meticulously packaged and, with the speed of digital agility, transported to the cloud, where the Azure platform stands ready to receive, process, and store this treasure trove of information. In the Azure cloud, the TCM data becomes a source of actionable insights. Healthcare professionals, researchers, and caregivers gain the ability to remotely access this data in real time, transcending geographical barriers. This empowerment brings forth a myriad of possibilities - from continuous patient monitoring and trend analysis to rapid diagnosis and timely interventions. The fusion of Node MCU, TCM devices, and Azure cloud technology symbolizes a harmonious marriage of cutting-edge electronics and the transformative potential of the cloud. This convergence reshapes healthcare paradigms, putting the power of comprehensive, personalized patient care at the fingertips of medical experts worldwide. In essence, Node MCU's integration in this context isn't just about technology; it's a catalyst for a brighter, healthier future.

D. Data Storage

In the rapidly evolving landscape of the Internet of Things (IoT), the Node MCU stands as a technological luminary, orchestrating a symphony of connectivity and innovation that redefines the way devices interact with the digital realm. Rooted in the capabilities of the ESP8266 microcontroller, the Node MCU takes center stage in the integration of IoT devices, exemplified by its role in the journey of transcutaneous monitoring (TCM) data from the tangible to the virtual realm. At the heart of this narrative lies Azure, the cloud computing juggernaut from Microsoft. Azure, akin to a celestial canvas for technological endeavors, offers an expansive playground where the Node MCU's prowess can truly flourish.

As the Node MCU diligently receives physiological data from TCM devices, it unfurls the wings of this information, channeling it towards the Azure IoT Hub. Azure IoT Hub, a beacon of connectivity in the azure expanse, acts as a vigilant gatekeeper, welcoming the influx of data with open arms. Its core function is to orchestrate a harmonious exchange between devices and the cloud, ensuring secure and efficient bi-directional communication. Just as a conductor guides an orchestra, Azure IoT Hub orchestrates the symphony of data, synchronizing the harmonies of transmitted information and received commands. From the Azure IoT Hub, the data embarks on a transformative pilgrimage towards Azure Storage. This storage repository, a digital sanctum mirroring a vault of boundless capacity, stands as a testament to Azure's commitment to preserving the fabric of information. Within its secure embrace, the physiological insights from the TCM devices find their digital dwelling, safeguarded for eternity. Yet, the Node MCU's role extends beyond transmission; it catalyzes the creation of an Azure Database for MySQL.

The database, a pinnacle of structured data management, serves as an arena for data manipulation and refinement. With MySQL's prowess, it endeavors to unravel the intricate tapestry of data, mining for patterns and insights that lie hidden within the numerical labyrinth. In the backdrop of this digital symphony, Spring Boot emerges as the conductor of backend operations. Spring Boot, akin to an expert maestro, crafts a seamless harmony between disparate components. It takes the baton from the Node MCU's relayed data, conducting a virtuoso performance that culminates in an interlude of impeccable orchestration. Spring Boot's genius lies in its ability to integrate with the Azure Database for MySQL, establishing a symphonic linkage that bridges raw data and refined insights. As the crescendo nears, Spring Boot conducts the grand finale – the creation of a User Interface (UI).

The interface, a window into the realm of healthcare insights, beckons healthcare professionals to partake in the symphony of data. It encapsulates the visual representation of physiological nuances, providing a medium for intuitive interaction and analysis. In summation, the Node MCU's virtuosity lies in its role as a technological enabler, ushering TCM data from the tangible to the digital realm. Azure, a cosmos of infinite possibilities, amplifies this journey by encompassing Azure IoT Hub, Azure Storage, and MySQL Database, each a star. Spring Boot harmoniously guides the backend symphony, culminating in a crescendo of a user interface. This integration isn't just a feat of technology; it's a magnum opus that harmonizes the ethereal realms of data, innovation, and healthcare, catalyzing a transformative wave in the technical panorama.

E. Web Application

In the realm of digital innovation, a sophisticated web application emerges, harnessed by the power of AngularJS, a dynamic front-end framework. This application's genesis witnesses the birth of a user interface (UI) crafted from the ground up, meticulously tailored to cater to the discerning needs of healthcare and domestic environments alike. As this digital marvel unfolds, it masterfully orchestrates a symphony of data connectivity, catalyzed by the enigmatic Node MCU, and ushers in an era of live patient monitoring and intelligent home automation.  AngularJS, a versatile JavaScript framework, takes center stage in this technological ballet. With its seamless integration and interactive capabilities, it lays the foundation for the UI's construction. This UI, akin to a digital canvas, is painstakingly designed and developed from scratch, embodying an intuitive and aesthetic interface that beckons users with its visual charm. As the Node MCU dons its role as a data emissary, it commences its journey, relaying physiological insights from the transcutaneous monitoring (TCM) device. This digital courier seamlessly transmits the data to the cloud, where it cascades into a reservoir of information.  Azure IoT Hub, a sentinel of connectivity, ensures the secure and bi-directional flow of data between the Node MCU and the digital realm, harmonizing the exchange of vital signs and commands. From the azure expanse of the cloud, the data is channeled into the AngularJS-powered web application. This integration unfolds as an intricate pas de deux, where data gracefully merges with code to paint a vivid picture on the UI canvas. The web application's responsive design and dynamic elements allow it to adapt to various devices, be it a computer screen in a hospital or a mobile device in a doctor's hand. At the core of this digital canvas lies the essence of live monitoring. Here, healthcare professionals, regardless of geographical confines, don the mantle of virtual guardians. They gain real-time access to the patient's physiological data, akin to peering through a digital window into the patient's well-being. This data dance, facilitated by AngularJS, unveils a continuum of information, enabling doctors to make informed decisions promptly and without boundaries. Beyond the realm of healthcare, this dynamic UI seamlessly transitions to the domestic landscape. Harnessing the same AngularJS-powered platform, the application metamorphoses into a conductor of intelligent home automation. From remotely adjusting thermostats to orchestrating smart lighting, the web application becomes a remote control for the modern home, enhancing convenience and energy efficiency. In essence, the intricate dance between AngularJS, the Node MCU, and Azure IoT Hub weaves a tapestry that transcends the boundaries of healthcare and domesticity. This digital saga, rooted in technology and innovation, harnesses the power of live data streaming to empower healthcare professionals with real-time insights and individuals with intelligent control over their living spaces. As this symphony of interconnected components unfolds, it exemplifies the seamless fusion of technology and human potential, revolutionizing the way we monitor health and interact with our environments.

IV. IMPLEMENTATION AND RESULTS

A. Plan of Execution

1. The transcutaneous monitoring device serves as a vital component in remote patient monitoring, offering a seamless way to collect and transmit essential medical data without the need for invasive procedures. This capability becomes particularly crucial in situations where patients require continuous monitoring, such as those with chronic illnesses or individuals recovering from major surgeries.
2. The Node MCU acts as the central processing unit of the monitoring device, managing data acquisition from various sensors connected to the patient. These sensors could include heart rate monitors, blood oxygen level sensors, temperature sensors, and more, depending on the specific medical parameters that need to be monitored.
3. Upon activation of the Wi-Fi module within the device, the Node MCU establishes a connection to a designated Wi-Fi network. This connection is essential for seamless data transfer and real-time communication with the cloud-based backend.
4. The bidirectional Mon link plays a crucial role in preparing the acquired medical data for transmission. It ensures that the data is formatted appropriately, encrypted for security, and made ready for transmission over the internet. This link also handles any potential data loss or corruption issues during transmission, guaranteeing the reliability of the transferred information.
5. The integration with Azure IoT Hub provides a robust platform for managing the incoming device data. Azure IoT Hub offers features such as device provisioning, message routing, and device management, which are essential for handling many monitoring devices transmitting data simultaneously. The Azure repository securely stores the collected data, adhering to strict data privacy and compliance standards.
6. The frontend user interface (UI) developed using Spring Boot and SQL Yog offers medical professionals a user-friendly way to visualize and interpret patient data in real-time. The UI can display trends, historical data, and critical alerts, enabling healthcare providers to make informed decisions promptly. The Spring Boot framework facilitates rapid development of the UI, while SQL Yog handles database interactions efficiently.
7. The remote monitoring system's ability to integrate multiple devices is a significant advantage. This feature allows medical practitioners to monitor multiple patients simultaneously, regardless of their physical location. It promotes efficient allocation of resources and enables timely interventions when patient conditions require attention.
8. Security measures implemented throughout the system are paramount. Data encryption at multiple levels ensures the confidentiality and integrity of patient data during transmission and storage. Access controls, authentication protocols, and regular security audits are essential to safeguard sensitive medical information and maintain compliance with healthcare data regulations.
9. Continuous improvement and updates are crucial to the success of the remote monitoring system. As medical technology advances, new sensors, algorithms, and communication protocols can be integrated to enhance the system's accuracy and reliability. Regular software updates ensure that the system remains up to date with the latest security patches and feature enhancements.
10. Overall, the integration of transcutaneous monitoring devices, IoT technology, cloud computing, and user-friendly interfaces holds the potential to revolutionize remote patient monitoring, improving patient outcomes, reducing healthcare costs, and expanding access to medical care. This innovative approach bridges the gap between patients and medical professionals, enabling effective healthcare delivery regardless of geographical constraints.

The TCM Device seamlessly connected to the Node MCU as shown in figure 3, leveraging the enabled Wi-Fi module within the Node MCU device. This connection empowers the device with wireless capabilities, facilitating efficient data transmission and remote monitoring.

Figure 4 shows how the Node MCU effectively retrieves data from the device by utilizing the Mon Link. This mechanism for a bidirectional data link assures correct and dependable data transmission, laying the groundwork for additional processing and eventual transmission to the cloud-based platform.

The first iteration of the user interface (UI). Starting with this interface, you can see how data moves without any interruption from cloud storage to real-time visualization in the user interface. By concluding the data journey at this crucial stage, users will be able to conveniently access and keep track of the information recorded.

It has the device's login page and emphasizes the significance of providing precise login information. This security measure ensures that only authorized personnel are granted entry, thereby safeguarding sensitive data, and maintaining strict control over device management and monitoring capabilities.

The home screen, which includes crucial details including the number of connected devices, alarm statuses, linked device serial numbers, hospital location, and device measurement status. Users can gain important insights on the state of the network and device functionalities from this thorough overview.

It has an in-depth view of each individual device together with helpful graphs that provide a clear indication of its state. Users of this feature-rich presentation are given in-depth insights that enable them to base their judgements on the trends in the visualized data. And the doctors can monitor from anywhere in the world.

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Conclusion

The project would be of a great help to the healthcare professionals and make their work easier. With help of this project the healthcare professionals won’t have to sit in front of the device to continuously monitor the patient status. They can just in their cabins and monitor the device which is probably in different room of the hospital. The healthcare professionals will be able to monitor multiple devices and there by the patient’s status at the same time with this web portal. Also, this web portal is straight forward, easy to understand and use, thus making the healthcare professionals work much easier. By analyzing trends in patient data, integrating advanced AI algorithms can offer predictive insights and early diagnosis of health risks. Direct patient data contribution would be made possible by expanding the system to include wearable technology and mobile apps, building a complete ecosystem for health monitoring. By providing remote monitoring and virtual consultations, the addition of telemedicine capabilities can help close the communication gap between patients and medical personnel.

References

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Copyright

Copyright © 2023 Syeda Noorain, Dr. Shankaraiah, Sumitha Vijayakumar . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.