Ijraset Journal For Research in Applied Science and Engineering Technology
Authors: Somenath Bhattacharya, Soumallya Chakraborty
DOI Link: https://doi.org/10.22214/ijraset.2024.64685
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Glycosides are one of the important constituents in medicinal plants worldwide. According to chemical classification, Glycosides are having different types like Anthraquinones, Saponins, Flavonoids, Flavonols, Coumarins, Furanocoumarins, etc. Various plants like Digitalis, Thevetia, Senna, Senega, Brahmi, Rhuberb, Aloe, Cascara, etc fall into this category. Glycosides are basically used Purgative, Cardiotonic, anti-depressant, coloring agent, diuretic, flavoring agent, antifungal, antidiabetic, antipyretic, stomachic, anthelmintic, antirheumatic agent, etc. Different parts of these plants like rhizomes, seeds, bark, leaves, etc are used as the potent sources of glycosides. These plants are grown in worldwide. In this review article, we focussed that the basic introduction and importance of glycosides, classification, their tests, distribution of different plants and their significance.
I. INTRODUCTION
Glycosides maintain important roles in medicinal and pharmaceutical world. Many medicinal plants contain a large amount of sugar like monosaccharides, disaccharides, trisaccharides, polysaccharides, etc. Glycoside is one of the organic conjugated moieties in where sugar part linked to non sugar part. The sugar part is known as glycone and the non sugar part is known as aglycon via glycoside linkage. On acid or enzymatic hydrolysis the glycosides break down into glycon and aglycon. Various medicinal plants like Thevetia, Digitalis, Squill, Cascara, Rhuberb, Brahmi, Senega, Aloe, Senna, etc. Pharmaceutically glycosides are used for the treatment of many disorders like diabetic, rheumatism, inflammation, fever, liver protection, different fungal diseases, etc. These plants are grown and cultivated in several countries as their different plant parts are also used for the sources of various glycosides [1-3].
II. TYPES OF GLYCOSIDES
Various types of glycosides are classified as followed [1, 4-5]:
III. ACTIVE CONSTITUENTS
Glycosides contain lots of active constituents in different plants. An active constituent like Rhein is obtained from Rhuberb whereas Sennosides A and B are obtained from Indian senna and Alexandrian senna. Another one important constituent is Aloe-emodin found from Aloe. Besides, Cascarosides A, B, C and D are found from Cascara. Like another active constituents Barbaloin, Carminic acid, Digoxin, Scillaren A, Diosgenin, Ouabain, Sinigrin, Hesperidin, Coumarin, Khellin, Xanthotoxin, Psoralen, Bacosides A, Hicogenin, Arbutin, Solasodine, Gentiopicrin, Iso-vanillin, Cantharidin, Amarogentin etc are observed under the glycosides [1, 6-7].
IV. IMPORTANCE IN PHARMACEUTICAL WORLD
Glycosides are used to cure different diseases in pharmaceutically. Like as Senna is used as purgative whereas Digitalis is used as cardiotonic. Glycyrrhiza is used as expectorant and treatment of peptic ulcer. Brahmi is followed for nervine tonic. Henna is used as antifungal. Garcinia is very useful for the treatment of rheumatism. Picrorrhiza is used as hepatoprotective agent. Gymnema is maintaining its antidiabetic property. Another one example is the treatment of leucoderma followed by Psoralea. Ammi is used for the treatment of vitiligo. Visnaga is smooth mucle relaxant [1, 8-10].
V. ISOLATION OF GLYCOSIDES
Glycosides are extracted via several methods. One of the useful methods is Sta-otto method. The drug is powdered and extracted with solvent like as alcohol by using soxhlet through the application of percolation below 450C for extraction of thermolabile glycosides. The extract is mixed with lead acetate to precipitate out tannins and impurities. Lead sulphide is added to lead acetate precipitate by using hydrogen sulphide gas. The extract is then filtered and concentrated to precipitate crude glycosides. The pure glycosides are obtained from crude glycosides by using different techniques like column chromatography, thin layer chromatography, etc. The pure isolated glycosides are then characterized by UV, IR, NMR and mass spectrometry [1, 3, 11].
VI. CHEMICAL TESTS
Various types of tests for different types of glycosides are followed [1, 3, 12]:
VII. DISTRIBUTION OF GLYCOSIDES
Table: Plant and Drug Description under Glycosides
Sl. No. |
Name of Drug |
Synonym |
Parts Used |
Family |
Scientific Name |
Geographical Source |
Active Constituents |
Uses |
1 |
Cascara [1, 13-14] |
Sacred Bark |
Dried bark |
Rhamnaceae |
Rhamnus purshiana |
North Carolina, Washington, West Canada, Kenya |
Cascarosides A, Cascarosides B, Cascarosides C, Cascarosides D, Aloe-emodin, Emodin, Chrysophanol |
Mild purgative, tonic, bitter stomachic |
2 |
Rhuberb [1, 15-16] |
Revandchini |
Dried rhizomes |
Polygonaceae |
Rheum palmatum, Rheum webbianum, Rheum emodi |
India (Kashmir, Sikkim), Tibet, South east China, Korea, West Germany |
Rhein, Aloe-emodin, Chrysophanol, Emodin, Physcion, Palmidin A, Palmidin B, Palmidin C, Glucogallin, Tannin, Catechin, Rheinolic caid, Pectin, Epicatechin |
Purgative, bitter stomachic |
3 |
Indian Senna [1, 17-18] |
Senna leaf |
Dried leaflets |
Leguminosae |
Cassia angustifolia, Cassia senna |
India (Tamil Nadu, Andra Pradesh, Gujarat, Rajasthan) |
Sennosides A, Sennosides B, Sennosides C, Sennosides D, Aloe-emodin, Rhein, Kaempferol, Isorhamnetin, Phytosterol, Myricyl alcohol, Chrysophanic acid, Rhein 8 –glucoside, Rhein 8-diglucoside, 8-glucoside |
Purgative |
4 |
Alexandrian Senna [1, 19-20] |
Egyptian senna |
Dried leaflets |
Leguminosae |
Cassia acutifolia |
Tropical Africa, Sudan |
Sennosides A, Sennosides B |
Purgative |
5 |
Senna Pods [1, 20-21] |
Senna fruit |
Dried ripe fruits |
Leguminosae |
Cassia angustifolia and Cassia acutifolia |
India, Africa |
Sennosides A, Sennosides B |
Purgative |
6 |
Aloe [1, 22-23] |
Kumari |
Dried juice of leaves |
Liliaceae |
Aloe vera, Aloe barbadensis, Aloe ferox, Aloe Africana, Aloe spicata, Aloe perryi |
India, Europe, Caribbean Islands, South and east Africa |
Aloe-emodin, Barbaloin, Aloesin, Aloin, |
Purgative |
7 |
Hypericum [1, 24-31] |
St. John's wort, Goat weed, Millepertuis |
Dried aerial parts |
Hypericaceae |
Hypericum perforatum |
India, England, Australia, Europe |
Hyperoside, Hyperforin, Hypericin |
Antidepressant |
8 |
Cochineal [1, 32-33] |
Coccus |
Dried female (full grown) insects of young larvae |
Coccidae |
Coccus cacti |
Central America, Mexico, Caribbean Islands |
Carminic acid, Carmine |
Coloring agent |
9 |
Thevetia [1, 34-36] |
Lucky nut tree |
Dried seeds |
Apocynaceae |
Thevetia peruviana, Thevetia nerifolia |
India, Florida, Hawaii, America, West Indies |
Thevetin A, Thevetin B, Peruvoside, Thevenerin, Neriifolin, Cerberin, Peruvosidic acid |
Cardiotonic |
10 |
Digitalis [1, 37-42] |
Foxglove leaves |
Dried leaves |
Scorphulariaceae |
Digitalis purpurea |
India, England, Europe, USA |
Digitoxigenin, Digitoxin, Gitoxin, Gitaloxin, Verodoxin, Digoxin, Purpurea glycoside A, Purpurea glycoside B, Lanatosides A, Lanatosides B, Lanatosides C, Glucoverodoxin |
Cardiotonic |
11 |
Indian Squill [1, 43-44] |
Jangli pyaz, Urginea, Sea onion |
Dried sliced bulbs |
Liliaceae |
Urginea indica |
India, Italy, Spain, France, Greece, Algeria |
Scillaren A, Scillaren B |
Cardiotonic, expectorant, stimulant, diuretic, emetic, cathartic |
12 |
European Squill [1, 45-46] |
White squill |
Dried sliced bulbs |
Liliaceae |
Urginea maritima |
Morocco, Algeria, France, Italy, Spain |
Scillaren A, Scillaren B |
Cardiotonic |
13 |
Red Squill [1, 47-48] |
Red variety of European squill |
Dried sliced bulbs |
Liliaceae |
Red variety (Urginea maritima) |
Morocco, Algeria, France, Italy, Spain |
Anthocyanin, Scilliroside, Scillirubroside |
Rat poison |
14 |
Ouabain [1, 49-50] |
G-strophanthin |
Dried seeds |
Apocynaceae |
Strophanthus gratus, Acokanthera schimperi |
Tropical Africa |
Ouabain, G- Strophanthidin, Ouabagenin, Rhamnose |
Cardiotonic |
15 |
Strophanthus [1, 51-52] |
Arrow poison |
Dried ripe seeds |
Apocynaceae |
Strophanthus kombe |
Tropical Africa |
Strophanthidin, Cymarol, β-cymarin, K-strophanthin |
Cardiotonic |
16 |
Mustard [1, 53-54] |
Black mustard |
Dried ripe seeds |
Cruciferae |
Brassica nigra |
India (West bengal, Uttar Pradesh, Bihar), USA |
Sinigrin |
Rubefacient, emetic, counter irritant |
17 |
White Cherry Bark [1, 55-56] |
Wild back cherry, Virginian prune bark, Cortex pruni |
Dried bark |
Rosaceae |
Prunus serotina |
USA, Canada, Florida, North Carolina |
Prunasin, p-coumaric acid |
Flavoring agent, mild sedative, expectorant |
18 |
Bitter Almond [1, 57-58] |
Aamygdala amara |
Dried ripe seeds |
Rosaceae |
Prunus amygdalus |
Iran, Italy, Spain, Morocco, France, Portugal |
Amygdalin |
Sedative, demulcent, flavoring agent |
19 |
Milk-thistle (Silymarin) [1, 59-64] |
Marian Thistile |
Ripe seeds |
Asteraceae (Compositae) |
Silybum marianum |
India (Kashmir), Canada, Europe, South America |
Silybin, Silydianin, Silyhermin, Silydianin, Silybinome, Silandrin, Neosilyhermin, Dehydrosilybin, Silycrystin, Deoxy silydianin, Desocysilycristin |
Liver disorders treatment, anti-depressant, bitter tonic |
20 |
Buck wheat [1, 65-66] |
Buck wheat |
Dried fruits |
Polygonaceae |
Fagopyrum esculentum |
USA, Japan, Russia |
Rutin |
Capillary bleeding and retinal hemorrhages treatment |
21 |
Gingko [1, 67-68] |
Kew tree, Maiden hair tree |
Drived leaves |
Gingkoaceae |
Gingko biloba |
East Asia, Europe, North America |
Gingkolides A, Gingkolides B, Gingkolides C, Ginkgetin, Kaempferol, Isorhamnetin, Quercetin, Isoginkgetin, Gingkolic acid, Bilobetin, Anthocyanins, Catechins, Sitosterol, Shikimic acid
|
Vascular disorders treatment |
22 |
Tonka bean [1, 69-70] |
Tonco seeds |
Dried seeds |
Leguminosae |
Dipteryx odorata |
Mexico, Brazil, Holland |
Coumarin |
Flavoring agent |
23 |
Ammi [1, 71-72] |
Ammi |
Fruits |
Umbelliferae |
Ammi majus |
India (Jammu and Kashmir), Egypt, Europe, West Africa |
Xanthotoxin, Bergapten, Imperatorin, Isopimpilin |
Vitiligo treatment |
24 |
Visnaga [1, 73-74] |
Khella, Pick tooth fruit |
Dried ripe fruits |
Umbelliferae |
Ammi visnaga |
Chile, Egypt |
Khelloside, Visnagin, Khellin |
Smooth muscle relaxant |
25 |
Psoralea [1, 75-76] |
Bavchi |
Dried ripe fruits |
Leguminosae |
Psoralea corylifolia |
India (Mahya Pradesh and Maharashtra), Sri Lanka |
Corylifolin, Isopsoralidin, Psoralenol, Bavachromanol, Psoralen, Coumarin, Raffinose, Psoralidin |
Leucoderma, leprosy, psoriasis and inflammatory treatment |
26 |
Mylabris [1, 77-78] |
Mylabris |
Dried beetles |
Meloidae |
Mylabris pustulata, Mylabris cichorii |
India, China |
Cantharidin |
Rubefacient, counter irritant |
27 |
Cantharides [1, 79] |
Spanish fly |
Dried beetles |
Meloidae |
Cantharis vasicatoria |
Europe, Russia, Spain, Italy, Romania |
Cantharidin, Cantharidic acid |
Rubefacient, counter irritant |
28 |
Anantmul [1, 80-82] |
Sariva |
Dried roots |
Asclepiadaceae |
Hemidesmis indicus |
India |
Iso-vanillin, Lupeol, Saponins, β sitosterol, a & b amyrins, Hemidesmin I, p-methoxy salicylic aldehyde, Hemidesminine |
Flavoring agent, anti-inflammatory agent, blood purifiers, rheumatism treatment |
29 |
Vanilla [1, 83-84] |
Baunilha |
Unripe fruits |
Orchidaceae |
Vanilla planifolia |
India (Kerala), Sri Lanka, Mexico, Madagascar |
Gluco-vanillin, Glucovanilic alcohol |
Flavoring agent |
30 |
Bearberry [1, 85-86] |
Uva ursi |
Dried leaves |
Ericaceae |
Arctostaphylos uvaursi |
North America, Scotland, Canada, North Europe |
Arabutin, Methyl arbutin, Ursolic acid, Quercetin, Quinones, Iriodoids, Ursone, Terpenoids, α-amyrin, β-amyrin |
Diuretic, astringent, Urethritis and cystitis treatment |
31 |
Solanum [1, 87-89] |
Solanum |
Dried fruits as well as berries |
Solanaceae |
Solanum khasianum |
India (Assam, Sikkim, Maharashtra), China, Myanmar |
Solasodine |
It is used as starting material for steroidal synthesis |
32 |
Dioscorea [1, 90-91] |
Yam |
Dried tubers |
Dioscoreaceae |
Dioscorea deltoidea, Dioscorea composita |
India (Punjab, Jammu and Kashmir, Tamil Nadu, West Bengal, Himachal Pradesh, Maharashtra), China, Nepal, USA, Mexico |
Diosgenin, Sapogenin, Smilagenin, β-isomer yammogenin, Epismilagenin |
It is used as starting material for steroidal synthesis |
33 |
Glycyrrhiza [1, 92-94] |
Yasti, Liquorice root, Mulethi |
Dried roots and stolons |
Leguminosae |
Glycyrrhiza glabra |
Spain, England, Iran |
Glycyrrhetinic acid, Carbenoxolone, Glycyrrhizin, Glycyramarin, Asparagin, |
Demulcent, expectorant, flavoring agent, antispasmodic agent, antiulcer agent, anti-inflammatory agent |
34 |
Safed Musali [1, 95-97] |
Safed musali |
Dried peeled tuberous roots |
Liliaceae |
Chlorophytum borivilianum |
India (Rajasthan, Gujarat, Madhya Pradesh, Maharashtra) |
Hecogenin |
Aphrodisiac, general tonic |
35 |
Brahmi [1, 98-100] |
Bacopa |
Fresh leaves and stems |
Scorphulariaceae |
Bacopa moniera |
India |
Bacosides A, Bacosides B, Brahmic acid, Asiatic acid, Herpestine, Brahmine |
Nervine tonic, antiasthmatic agent, antiepileptic agent, diuretic, anticancer agent |
36 |
Shataveri [1, 101-104] |
Shutmuli |
Dried roots and leaves |
Liliaceae |
Asparagus racemosus |
India (Maharashtra), Africa, Australia |
Shatavarin I, Shataverin II, Shataverin III, Shataverin IV, Rutin, Diosgenin, Quercetin |
Galactogogue, diuretic, tonic |
37 |
Jalbrahmi [1, 105-108] |
Mandukparni |
Dried herb |
Umbelliferae |
Centella asiatica |
India, Srilanka, Indonesia, Madagascar, Australia, Africa, Vietnam, China |
Asiaticoside, Madecassoside |
Nervine tonic, sedative, antistress agent, spasmolytic agent, leprosy and syphilis treatment |
38 |
Momordica [1, 109-110] |
Karela, Bitter gourd |
Fresh and dried green fruits |
Cucurbitaceae |
Momordica charantia |
India |
Mmomordicin, Charantin, Saponins |
Hypoglycemic agent, stomachic, tonic, carminative, cooling agent, antirheumatic agent, disorders of spleen and liver treatment, gout treatment, antidiabetic agent |
39 |
Senega [1, 111-112] |
Rattlesnake root |
Dried root and rootstock |
Polygalaceae |
Polygala senega |
USA, Japan, East Canada |
Polygallic acid, Senegin, Senegenic acid, Presenegenin |
Expectorant, stimulant, gastritis and bronchitis treatment |
40 |
Ginseng [1, 113-120] |
Panax, Pannag, Ninjin |
Dried root |
Araliaceae |
Panax ginseng |
USA, Canada, Russia, Korea, China, Japan |
Ginsenosides, Panaxosides, Panaxatriol, Panaxadiol, Oleanolic acid |
Stimulant, tonic, demulcent, gastritis and anaemia treatment, sedative, aphrodisiac, immunomodulatory agent |
41 |
Gokhru [1, 121-122] |
Tribulus |
Dried ripe fruits |
Zygophyllaceae |
Tribulus terrestris |
India, Tibet, Sri Lanka |
Harmine, Harman, Teresterosin A, Teresterosin E, Tribulosin, Gitogenin, Diosgenin, Ruscogenin, Chlorogenin |
Aphrodisiac, diuretic, tonic, gout treatment, ingredient of ayurvedic products |
42 |
Quillaia [1, 123-124] |
Soap bark |
Dried inner part of bark |
Rosaceae |
Quillaja saponaria |
India (Uttar Pradesh and Punjab), Peru, Chile |
Quillaia-sapotoxin, Quillaic acid, Tannin, Sucrose |
Emulsifying agent, detergent, Shampoo preparation, reflex expectorant |
43 |
Gentian [1, 125-126] |
Gentiana |
Dried root and rhizome |
Gentianaceae |
Gentiana lutea |
Europe |
Gentiopicroside, Gentianin, Amarogentin, Gentinin, Amaroswerin |
Bitter tonic, stomachic, improve appetite |
44 |
Chirata [1, 127-128] |
Chirayata |
Dried plant |
Gentianaceae |
Swertia chirata |
India (Kashmir, Madhya Pradesh), Bhutan, Nepal |
Gentiopicrin, Sweroside, Chiratin, Amarogentin, Ophelic acid, Gentianine, Gentiocrucine |
Antipyretic, bitter stomachic, febrifuge, bitter tonic, dyspepsia treatment |
45 |
Picrorrhiza [1, 129-132] |
Indian gentian, Kutki |
Dried rhizome |
Scorphulariaceae |
Picrorrhiza kurroa |
India (Uttar Pradesh, Himachal Pradesh, Punjab, Sikkim, Kashmir), China |
Picroside I, Picroside II, Aamarogentin, Kutkoside |
Bitter tonic, febrifuge, antiperiodic, hepatoprotective agent, laxative, antibacterial agent |
46 |
Kalmegh [1, 133-134] |
Andrographis, Kirayat |
Dried leaves and shoots |
Acanthaceae |
Andrographis paniculata |
India (Karnataka, West Bengal, Tamil Nadu, Andhra Pradesh, Madhya Pradesh, Uttar Pradesh, Maharashtra), Sri Lanka |
Andrographolide, Kalmeghin |
Bitter tonic, anthelmintic agent, stomachic, hepatoprotective agent, anti-dysentery agent, dyspepsia treatment, anti-typhoid agent |
47 |
Quassia [1, 135] |
Bitter wood |
Dried stem wood |
Simarubaceae |
Picrasma excelsa |
Caribbean Islands (Barbados and Jamaica) |
Quassin, Neoquassin, Isoquassin, 18 hydroxy quassin |
Bitter tonic, anti-insecticidal agent |
48 |
Gudmar [1, 136-138] |
Gymnema, Madhunashini |
Dried leaves |
Asclepiadaceae |
Gymnema sylvestre |
India |
Gymnemic acid I, Gymnemic acid II, Gymnemic acid III, Gymnemic acid IV, Pentriacontane, Phytin, d-quercitol, Inositol |
Anti-diabetic agent, laxative, diuretic, stomachic, stimulant |
49 |
Stevia [1, 139] |
Stevia |
Dried roots and leaves |
Asteraceae |
Stevia reboundians |
India, Brazil, Japan, Mexico, USA, China, Canada, Korea, Indonesia |
Rebandioside A, Rebandioside C, Sterioside, Stevioside, Dulcoside A |
Sweetening agent, anti-diabetic agent, anti-inflammatory agent, anti-bacterial agent, antiseptic agent, digestive tonic, different skin problems like acne, dermatitis, eczema treatment |
50 |
Henna [1, 140-146] |
Egyptian privet |
Dried or fresh leaves |
Lythraceae |
Lawsonia inermis |
India, Africa, Sudan, Egypt, Caribbean Islands, China, Florida |
Lawson, Hennoside A, Hennoside B, Hennoside C |
Anti-fungal agent, anti-bacterial agent, Hair dye |
51 |
Manjishta [1, 147-151] |
Indian maddar |
Dried stems |
Rubaceae |
Rubia cordifolia |
India, Nepal, Iran |
Rubiadin, Purpurin, Manjisthin |
Used in leucoderma, different skin problems and arthritis treatment, blood purifying agent |
52 |
Garcinia [1, 152-153] |
Vilayati imli |
Dried de-seeded fruits |
Guttiferae |
Garcinia combogia |
India, Sri Lanka |
Hydroxy citric acid, Tartaric acid |
Anti-rheumatic agent, flavoring agent, condiment, antiseptic, used in digestive disorders |
53 |
Guduchi [1, 154-162] |
Amrita, Giloe, Gulvel, Tinsopora |
Dried leaves and stem |
Menispermaceae |
Tinospora cordifolia |
India (Assam, Bihar), Sri Lanka, Indonesia |
Tinosporine, Tinosporidine, Tinosporaside, Tinosporoside, Berberine, Gilonin, Giloin, Syringin, Cordifolioside A, Palmarin, Chasmanthin, Columbin, Tinosporic acid, Tinosporol |
Anti-diabetic agent, anti-rheumatic agent, anti-hepatitis agent, used in jaundice, skin and arthritis treatment, immunostimulant agent, bitter tonic |
Glycosides are having very important role in medicinal world for treating different types of diseases. These are also much signified for their various function in maintaining the plant growth, development and protection. Glycosides content various plants like Brahmi, Senega, Aloe, Senna, Digitalis, Thevetia, etc are cultivated in different parts of world. Different parts of the plants are followed traditionally for the rich sources of various glycosides like C-glycosides, N-glycosides, O-glycosides and S-glycosides. Lots of extraction techniques and chemical tests are present to show the extraction of glycosides. Different types of pharmaceutical formulations like aloe gel, henna shampoo, Brahmi tonic, etc are available to cure various problems.
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Copyright © 2024 Somenath Bhattacharya, Soumallya Chakraborty. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Paper Id : IJRASET64685
Publish Date : 2024-10-19
ISSN : 2321-9653
Publisher Name : IJRASET
DOI Link : Click Here