Synthesis, Purification, Identification of Aspirin and Evaluation on the Basis of Drug Release with Different Aspirin Formulation

Abstract

Aspirin is 2-acetoxy benzoic acid. It is one of the derivatives of Benzoic acid. It is white crystalline fine powder. Aspirin is acetylated product. This drug is under non-steroidal anti-inflammatory drug in which they block cyclooxygenase receptor by inhibiting COX pathway. The drug can block the production of prostaglandin derivative. Therefore they can be used as an analgesic cum anti-inflammatory. As we know prostaglandin is the inflammation mediator in human body, therefore, by blocking their production, Aspirin can used as pain killer as well as analgesic. It is also used as platelet aggregating agent. The present study focuses on the synthesis, purification, identification and evaluates better drug release with different aspirin formulation (tablet).

Introduction

I. INTRODUCTION

Aspirin is non steroidal anti inflammatory drugs as because it is having no steroidal nucleus. It is the acetylated derivative of Benzoic acid. The drug is basically white fine crystalline powdered.

 Aspirin is used as analgesic cum anti-inflammatory drug.

It blocks cyclooxygenase (COX) receptor through COX pathway as this receptor is capable to form prostaglandins or PG derivatives. PG derivative is called as pain or inflammation mediator. Therefore by blocking those derivatives, Aspirin can inhibit the cyclooxygenase as well as they can be used for the treatment of pain [1].

Another one mechanism of the drug is based on their platelet aggregation.

Aspirin can also inhibit the production of thromboxane synthesis through COX pathway.

Thromboxane is important parameter related to platelet as well as coagulation pathway. By blocking thromboxane, platelets can be aggregated. Therefore, Aspirin can be used as blood thinner agent as well as it is used in the treatment of myocardial heart infraction and heart attack.   

Aspirin is generally used as long term treatment with solid dosage formulations. Solid dosage forms are basically composed of solid compressed fine particles with different excipients, binders, etc. Solid dosage forms of Aspirin are having improved drug release property into the targeted site. In the category of solid dosage form, Aspirin tablet is usually prepared by weight granulation method. Besides main drug, some other excipients are mixed into it.

Different types of lubricants, glidants, binders, coating agents, polishing agents, coloring agents, flavoring agents, preservatives can be added to the main active drug for enhancement of the formulations consistency [2-4].

 A. Binder

Binders are helps to hold the ingredients in a tablet each other and ensure that tablets can be formed with required mechanical strength.

IV. ACKNOWLEDGEMENT

 Authors would gratefully thanks to the library department and laboratory technicians of Global College of Pharmaceutical Technology, Nadia, West Bengal, India for successfully completing this research work.

Conclusion

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Copyright

Copyright © 2022 Soumallya Chakraborty, Somenath Bhattacharya, Rohan Pal, Sourav Biswas, Sanjit Mandal, Sourav Saha, Dr. Arin Bhattacharjee. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.