Ayurveda has mentioned various principles and treatment modalities. Also, it described various aspects and unique concepts of health in Ayurveda1. Now a days, everyone is more predisposed to disorders which occurs due to the lifestyle choices & faulty dietary habits. Vatarakta is one of such lifestyle diseases, which typically affects Marma-asthi-sandhi (vital part of the body, bone, & joint). Due to the numerous etiological factors, there is vitiation of the vata and derangement of the rakta. The vitiated rakta produces hindrances to the pathway of the vata. Thus, this obstruction to the vata in siras (blood vessels) by rakta causes further aggravation of the vata. Which again vitiates the rakta. That leads to the onset of the disease Vatarakta. The ailment is described by a number of synonyms, including Vatarakta, Khudavata, Vatabalasa, and Adhyavata. Vatarakta vyadhi has been thoroughly described by Acharya Charaka. Acharya Sushruta has outlined Vatarakta disease under the concept of Vatavyadhi Adhyaya, which is named as ‘Vatashonita’. The distinctive example of Avarana janya vata vyadhi is Vatarakta. Thus, Samprapti vighatana (breaking the pathogenesis) can be attained by first alleviating Avarana (obstruction to the routeway of vata dosha by rakta dhatu), followed by pacifying the vitiated vata and pitta. Therefore, in this case report, Kokilaksha Ghanavati was given for about 14 days in the management of Vatarakta, and the evaluation centered on both subjective as well as objective metrics. Noteworthy improvement was seen.
Introduction
I. INTRODUCTION
Vatarakta or Vatashonita is one of the most prevalent and commonly found lifestyle disorders in modern times. It is correlated with the Gouty arthritis or Gout in modern science, as the etiological factors and clinical characteristics of Vatarakta are much alike those of the Gout. Vatarakta has evolved due to consumption of Vidahi-anna (intake of irritable food items), Viruddha-ahara (incompatible meals), jagarana (vigil throughout the night), abhighata (trauma), etc. Nidanas (etiological causes)2. Numerous Acharyas have stated that Sukumara (delicate) persons are more inclined to develop Vatarakta. While Vatarakta can cause a wide range of signs & symptoms, Ruka (pain), Stambha (stiffness), Shotha (swelling), redness and warmth in the afflicted areas are the most typical ones. Pain is a chief symptom that interferes with the patient’s activities of daily living. It is of 2 types; includes Uthana & Gambhira Vatarakta3.
Gout is defined as an inflammatory condition in which uric acid builds up in the blood. It is an inflammatory response to the deposition of crystals of monosodium urate [MSU] in the joints. It has become more prevalent and widespread in today’s era, with a prevalence rate of 2.0 to 2.6 per 1000 patients and rising day by day.
Gout is the most common inflammatory arthritis that strikes both men and elderly women, with a greater than 5:1 male predominance. The risk of developing Gout increases with the age and with serum uric acid levels, which are normally distributed in the general population4.
According to Acharya Sushruta, the disease initially impacts feet, occasionally also affecting the hands at first (anguli, tala, gulpha, and manibhanda) and eventually advancing to other body parts. Which is pretty much the same manner in which rat poison spreads6.
A. Objective
To study the role of Ayurveda in the management of Vatarakta.
II. PATIENT INFORMATION
Case Report: A 27-year-old, college going male patient visited Dr. D. Y. Patil Ayurved College, Pimpri, Pune, with prime complaints of pain, swelling and tenderness at Right Metatarsophalangeal joint [MTP] accompanied by mild difficulty in movement that had persisted for 6 weeks.
Past History: No prior history of any significant major illness in the past.
Family History:There was no evidence of any family history.
Personal history
a) Gym: Workout 4 times a week for a year while taking protein supplements.
b) Weekly Intake of non-veg: one or two times.
c) Alcohol consumption: on occasion, once a month.
III. CLINICAL FINDINGS
Redness and warmth over the joint [MTP]
A. General Examination of Patient
The blood pressure (120/70 mm of Hg), pulse rate (80 bpm), along with body temperature (98.6 °F) were all within the range of normal.
B. Systemic Examination
The respiratory, cardiovascular and central nervous systems did not exhibit any unusual findings corresponding to the systemic assessment.
IV. DIAGNOSTIC CRITERIA OF ASSESSMENT7
Below is a list of each assessment parameter.
A. Subjective Criteria
1) Sandhi Shoola (Pain)
Grade
Description
0
No pain at all
1
Occasional, tolerable agony
2
More frequent, moderate form of pain
3
Everyday / intense agony that wakes you up at night / following after or along with every movement
2) Sandhi Shotha (Swelling)
Grade
Description
0
Absence of swelling
1
Swelling present but not obvious
2
Less than two joints have evident swelling
3
More than two joints exhibit visible swelling
3) Sankochan (Stiffness)
Grade
Description
0
No difficulty in movement
1
Mild impairment in movement
2
Difficulty in movement
3
Inability to move at all / absolute immobility
4) Sparsha-asahatva (Tenderness)
Grade
Description
0
No tenderness at all
1
Mild degree of tenderness results from deep touch
2
Little touch causes a moderate type of tenderness
3
Severe form of tenderness caused by slightest touch
5) Daha [Burning Sensation]
Grade
Description
0
Absence of burning sensation
1
Transitory, no approach to prevent it
2
On frequent basis, self-approach for its aversion
3
Consistently, seeking medical guidance
6) Discoloration (Local color changes in the skin)
Grade
Description
0
No color change
1
Mild color change / Close to normal, which seems like normal to a certain extent
2
Reddish coloration of the afflicted part
3
Discoloration that is slight reddish black
4
Blackish coloration of the afflicted part
Objective criteria: For the trial, objective parameters of assessment were serum uric acid level and VAS score.
V. THERAPEUTIC INTERVENTION
Table Number 1
Drug
Dose
Frequency
Time
Duration
Anupana
Kokilaksha Ghanavati
250 mg
2 - 0 - 2
Before Meal
14 Days
(With Follow-up on day 7th)
Ushnodaka
VI. FOLLOW-UP AND OUTCOMES
In this case, follow-up revealed an obvious improvement, and the following observations occurred.
Table Number 2
Symptoms
0th day
7th day
14th day
Pain
3
2
1
Swelling
2
2
1
Stiffness
1
1
0
Tenderness
2
1
1
Burning sensation
2
1
0
Discoloration
2
2
1
Table Number 3: VAS Score –
VAS Score
0th day
7th day
14th day
7
4
1
Table Number 4: The following outcomes were seen when serum uric acid was measured both before and after medicinal intervention.
Serum Uric Acid
Before Intervention
After Intervention
8.1 mg/dl
5.8 mg/dl
Serum uric acid reports before and after the medical intervention are shown in Figures 1 & 2.
Samprapti Vighatana (disintegrating the pathogenesis) starts by clearing the obstruction created by aggravated and vitiated rakta. Madhura rasa is the predominant rasa and Amla and Tikta rasa are two of the anurasas found in Kokilaksha. Pitta dosha is calmed by tikta & madhur rasa. Applying the principle of Ashraya-Ashrayi bhava, as tikta & madhura rasa alleiviate the vitiated pitta, it as well pacifies the vitiated rakta. Hence, the vitiated rakta that was obstructing Vata’s passage is eliminated.
Kokilaksha has Madhura rasa, Madhura vipaka and Sheeta virya. Thus, these properties make the drug Vata-pitta shamak (body humors) which are primary dosha’s involved in etiopathogenesis of the disease.
It also has Mutrala (diuretic) and Shotha-hara (reduces oedema) characteristics8. Shotha over hand, feet and other part of body is often seen in vatarakta patient. Likewise, the nature of this drug is guru and snigdha.
The aforementioned properties contributed to treating the disease by lessening the signs and symptoms commonly seen, i.e., pain, swelling, burning sensation, and tenderness.
The study done on kokilaksha, confirms that the isolated compound from ethanolic extract of Asteracantha longifolia root, has anti-inflammatory property. possibly because B-sitosterol, a polyphenolic compound, is there9. The phytoconstituent lupeol was found in Asteracantha longifolia, and it demonstrated anti-arthritic properties10. These research studies suggest that kokilaksha may be able to relieve some signs and symptoms of gout, like joint pain, swelling, and discoloration, by reducing inflammation.
Conclusion
The patient exhibited substantial positive outcomes by the time trial accomplished. As the subjective metrics considered for the study, i.e. pain, swelling, stiffness, etc., were lessened, Also, serum uric acid level measured post intervention was within the standard range. Therefore, in order to improve patient care, advance our knowledge of medicine, and to develop effective Vatarakta management strategies, this research work is essential; nevertheless, since this is a single case study, further exploration is required.
References
[1] Chakrapani, Charaka Samhita, edited by Vaidya Jadavaji Trikamji Acharya, Chaukhambha Publications, New Delhi, Reprint 2017, Sutrasthana, 30/26, 187.
[2] Vagbhatta, Brahmanand Tripathi, Ashtanga Hridaya, Chaukhamba Sanskrit Pratishthana, Delhi, Reprint 2014, Nidanasthana, 16/1-4, 545.
[3] Chakrapani, Charaka Samhita, edited by Vaidya Jadavaji Trikamji Acharya, Chaukhambha Publications, New Delhi, Reprint 2017, Chikitsasthana, 29/19, 628.
[4] Brian R. Walker, et al, Davidson’s Principles & Practice of Medicine, 25th chapter, Reprint 2014, 22nd edition, 1087.
[5] Vagbhatta, Brahmanand Tripathi, Ashtanga Hridaya, Chaukhamba Sanskrit Pratishthana, Delhi, Reprint 2014, Nidanasthana. 16/4, 545.
[6] Susruta Samhita, Kaviraja Ambikadutta Shastri, Part 1 Chaukhambha Sanskrit Sansthan, Varanasi, Reprint 2016, Page no. 300
[7] Hutchinsons clinical method, edited by Michael Glynn, William drake, 23rd edition, 2012, 157-143.
[8] Pandey G.S. Bhavprakasha Nighantu of bhavamishra, commentary by Chunekar K.C., Guduchyadi varga, verse 224-225, Varanasi - Chaukhambha bharti academy, 2015, Pg.- 402.
[9] Samrit SR, Kamble Nidhita, Dambhare Akanksha, Hemke Atul, Umekar Milind. Preliminary phytochemical screening of ethanolic extract of Astercantha longifolia (Hygrophylla schulli) roots along with various activities. World journal of pharmaceutical research. 2020; 9(15):1267-1279.
[10] Patra Arjun, Jha Shivesh, Murthy PN. Phytochemical and Pharmacological Potential of Hygrophila spinosa T. Anders. Phcog Rev. 2009; 3(6): 330-341.